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7-Hydroxymitragynine (7-OH): What You Need to Know

7-OH is one of the most pharmacologically potent compounds in the kratom plant, and in its concentrated commercial form it essentially functions as a powerful opioid. The “research chemical” and “natural supplement” framing used to market it obscures what the science actually shows: a compound that behaves like a strong opioid, carries opioid risks, and currently operates in a largely unregulated market.

Anyone considering using it should be aware that the legal status is uncertain, the safety profile in humans is poorly established, and the potential for dependence and serious harm is real.

7-Hydroxymitragynine, commonly called “7-OH,” is a naturally occurring alkaloid found in the Mitragyna speciosa plant — better known as kratom — a tropical tree native to Southeast Asia, particularly Thailand, Indonesia, Malaysia, and Papua New Guinea.

While it exists in small concentrations in the raw kratom leaf (typically less than 2% of total alkaloid content), 7-OH has become the subject of intense scientific, regulatory, and public health interest due to its remarkably potent pharmacological activity.

Looking for 7OH powder for sale? Our premium, lab-tested 7-hydroxymitragynine powder is third-party verified for potency and purity. Each batch undergoes rigorous testing at NN, SD Pharma, and Renegade Labs, ensuring consistency across all concentrations.

There is currently several vendors selling powders with claims of %s like 97 or 99.5, they are completely fabricating results or even paying labs to put higher #e which is not correct! This should be the first red flag as a consumer. Those same batches have been retested, and have been found to be a whopping 10-20% lower then advertised. All domestic and thai powders are always maximum 90-95% at best. Typically source labs provide the highest % so most vendors feel the need to use those as the lab report and not the % from additional third party testing. We send our product to several third party labs and utilize those %s for our listing. Here at PS, we provide you with the most accurate %s to ensure everyone gets their moneys worth, if third party lab shows % is lower, that’s the % we utilize!

Premium 7OH Powder for Sale | Lab-Verified 7-Hydroxymitragynine Powder

How It Works

7-OH is an opioid receptor agonist, meaning it binds to the same receptors in the brain and body that classical opioids like morphine and oxycodone target. Specifically, it has a strong affinity for the mu-opioid receptor (MOR), which is responsible for pain relief, sedation, and euphoria — but also for respiratory depression, the primary mechanism behind opioid overdose deaths.

What makes 7-OH particularly notable in research circles is its potency. Studies have shown it to be significantly more potent than morphine at the mu-opioid receptor — some research suggests anywhere from 13 to 46 times more potent by weight. This is striking given that the parent plant, kratom, is often marketed as a “natural” and “mild” alternative to prescription opioids.

Beyond the mu-opioid receptor, 7-OH also interacts with delta and kappa opioid receptors, as well as adrenergic receptors. This multi-receptor profile contributes to its complex effects and differentiates it somewhat from traditional opioids, though researchers caution that this distinction doesn’t make it safer.

Natural vs. Synthetic / Semi-Synthetic Forms

This is where the “research chemical” label becomes important. In its natural state, 7-OH exists in kratom leaves in very small quantities. The body also produces some 7-OH through metabolic conversion of mitragynine (kratom’s primary alkaloid) after ingestion — this is actually thought to be a major reason kratom produces opioid-like effects at all.

However, the 7-OH sold as a research chemical or sold in some supplement markets is typically semi-synthetic — chemically isolated or synthesized to produce a concentrated product far more potent than anything found in a kratom leaf. Concentrated 7-OH products (powders, capsules, tinctures) have flooded certain online and retail markets in the US, often marketed as kratom extracts or legal opioid alternatives.

This distinction matters enormously from a safety standpoint. Chewing kratom leaves delivers a modest, slow dose of 7-OH via metabolism. Taking a concentrated 7-OH product delivers a direct, powerful opioid hit that the body processes very differently.

Effects

Users who take 7-OH products report effects that closely mirror classical opioids:

• Strong analgesia (pain relief)
• Sedation and relaxation
• Euphoria and mood elevation
• Reduced anxiety
• At higher doses: nausea, dizziness, and cognitive impairment

Because it hits opioid receptors so powerfully, it also carries the full spectrum of opioid risks — including physical dependence, withdrawal syndrome, and overdose potential, particularly when combined with other central nervous system depressants like alcohol, benzodiazepines, or other opioids.

Research & Medical Interest

Despite — or because of — its risks, 7-OH has attracted legitimate pharmaceutical research interest. The core question researchers are trying to answer is: can you design an opioid that provides pain relief without causing respiratory depression or addiction?

Some studies have explored whether 7-OH’s unique receptor binding profile (particularly its activity at non-mu receptors) might make it a candidate for a so-called “biased agonist” — a drug that activates the pain-relieving pathways of opioid receptors while bypassing the pathways that cause dangerous side effects. Early research was cautiously optimistic, but more recent animal studies have tempered enthusiasm, suggesting 7-OH does produce respiratory depression and has significant abuse potential in line with traditional opioids.

No 7-OH-based drug has cleared clinical trials or received FDA approval. It remains a research compound, not a medicine.

7-OH is one of the most pharmacologically potent compounds in the kratom plant, and in its concentrated commercial form it essentially functions as a powerful opioid. The “research chemical” and “natural supplement” framing used to market it obscures what the science actually shows: a compound that behaves like a strong opioid, carries opioid risks, and currently operates in a largely unregulated market. Anyone considering using it should be aware that the legal status is uncertain, the safety profile in humans is poorly established, and the potential for dependence and serious harm is real.

There is currently several vendors selling powders with claims of %s like 97 or 99.5, they are completely fabricating results or even paying labs to put higher #e which is not correct! This should be the first red flag as a consumer. Those same batches have been retested, and have been found to be a whopping 10-20% lower then advertised. All domestic and thai powders are always maximum 90-95% at best. Typically source labs provide the highest % so most vendors feel the need to use those as the lab report and not the % from additional third party testing. We send our product to several third party labs and utilize those %s for our listing. Here at PS, we provide you with the most accurate %s to ensure everyone gets their moneys worth, if third party lab shows % is lower, that’s the % we utilize!

Premium 7OH Powder for Sale | Lab-Verified 7-Hydroxymitragynine Powder

How It Works

7-OH is an opioid receptor agonist, meaning it binds to the same receptors in the brain and body that classical opioids like morphine and oxycodone target. Specifically, it has a strong affinity for the mu-opioid receptor (MOR), which is responsible for pain relief, sedation, and euphoria — but also for respiratory depression, the primary mechanism behind opioid overdose deaths.

What makes 7-OH particularly notable in research circles is its potency. Studies have shown it to be significantly more potent than morphine at the mu-opioid receptor — some research suggests anywhere from 13 to 46 times more potent by weight. This is striking given that the parent plant, kratom, is often marketed as a “natural” and “mild” alternative to prescription opioids.

Beyond the mu-opioid receptor, 7-OH also interacts with delta and kappa opioid receptors, as well as adrenergic receptors. This multi-receptor profile contributes to its complex effects and differentiates it somewhat from traditional opioids, though researchers caution that this distinction doesn’t make it safer.

Natural vs. Synthetic / Semi-Synthetic Forms

This is where the “research chemical” label becomes important. In its natural state, 7-OH exists in kratom leaves in very small quantities. The body also produces some 7-OH through metabolic conversion of mitragynine (kratom’s primary alkaloid) after ingestion — this is actually thought to be a major reason kratom produces opioid-like effects at all.

However, the 7-OH sold as a research chemical or sold in some supplement markets is typically semi-synthetic — chemically isolated or synthesized to produce a concentrated product far more potent than anything found in a kratom leaf. Concentrated 7-OH products (powders, capsules, tinctures) have flooded certain online and retail markets in the US, often marketed as kratom extracts or legal opioid alternatives.

This distinction matters enormously from a safety standpoint. Chewing kratom leaves delivers a modest, slow dose of 7-OH via metabolism. Taking a concentrated 7-OH product delivers a direct, powerful opioid hit that the body processes very differently.

Effects

Users who take 7-OH products report effects that closely mirror classical opioids:

• Strong analgesia (pain relief)
• Sedation and relaxation
• Euphoria and mood elevation
• Reduced anxiety
• At higher doses: nausea, dizziness, and cognitive impairment

Because it hits opioid receptors so powerfully, it also carries the full spectrum of opioid risks — including physical dependence, withdrawal syndrome, and overdose potential, particularly when combined with other central nervous system depressants like alcohol, benzodiazepines, or other opioids.

Research & Medical Interest

Despite — or because of — its risks, 7-OH has attracted legitimate pharmaceutical research interest. The core question researchers are trying to answer is: can you design an opioid that provides pain relief without causing respiratory depression or addiction?

Some studies have explored whether 7-OH’s unique receptor binding profile (particularly its activity at non-mu receptors) might make it a candidate for a so-called “biased agonist” — a drug that activates the pain-relieving pathways of opioid receptors while bypassing the pathways that cause dangerous side effects. Early research was cautiously optimistic, but more recent animal studies have tempered enthusiasm, suggesting 7-OH does produce respiratory depression and has significant abuse potential in line with traditional opioids.

No 7-OH-based drug has cleared clinical trials or received FDA approval. It remains a research compound, not a medicine.

7-OH is one of the most pharmacologically potent compounds in the kratom plant, and in its concentrated commercial form it essentially functions as a powerful opioid. The “research chemical” and “natural supplement” framing used to market it obscures what the science actually shows: a compound that behaves like a strong opioid, carries opioid risks, and currently operates in a largely unregulated market. Anyone considering using it should be aware that the legal status is uncertain, the safety profile in humans is poorly established, and the potential for dependence and serious harm is real.